# Opentrons ventilation

**URL:** <https://accelerated-discovery.org/t/opentrons-ventilation/528>\
**Category:** Tools\
**Created:** [May 13, 2025, 6:26pm UTC](https://accelerated-discovery.org/t/opentrons-ventilation/528 "2025-05-13T18:26:51Z")\
**Posts on this page:** 1\
**Showing post:** 2

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**Author:** ![sgbaird](https://yyz1.discourse-cdn.com/flex003/user_avatar/accelerated-discovery.org/sgbaird/32/341_2.png) [@sgbaird](https://accelerated-discovery.org/u/sgbaird)\
**Post date:** [May 14, 2025, 8:44pm UTC](https://accelerated-discovery.org/t/opentrons-ventilation/528/2 "2025-05-14T20:44:43Z")

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cc @OwenMelville, @nipun.0092 (polymer SDL) who are interested in something similar: [Open-Air Chemistry Setup --- Overcoming limitations?](https://accelerated-discovery.org/t/open-air-chemistry-setup-overcoming-limitations/515)

Based on some quick searches:

- [https://support.opentrons.com/s/article/Chemical-resistance-of-Opentrons-pipettes](https://support.opentrons.com/s/article/Chemical-resistance-of-Opentrons-pipettes)
- [Advancing Organic Chemistry Research with Automation: Michael Rourke](https://opentrons.com/archives/customer-stories/opentrons-user-interview-with-northwestern-university)

(Excerpt from case study above, they stuck it in a glovebox)

> For example, we’re very proactive about safety here at Northwestern: organic solvents are flammable, and using them is a real risk. The ability to transition reaction setup to an automated system in a controlled environment such as an inert glove box has obvious advantages

Some other random thoughts that might help make the case:

- use the OT-2 pipette to pick up caps with “fake tips” and place on top of vials when not in use (rather than a septum needle workflows) (I think @FrantzLD is doing this, @Lilo 's group too with an electromagnet tool)
- install a sensor that measures VOCs or similar and issue a warning or alert if it’s abnormally high. Maybe have a baseline. Happy to elaborate - we have some sensors
- as part of SOP, minimizing the amount of solvent contained within the OT-2 at a given time (i.e., lower damage if explosion happens)
- use a shielding gas (e.g., from N2 generator) to simulate a glovebox environment
- Throttle the OT-2 speed (i.e., put less strain on the DC motors?)
- [tabletop fumehoods](https://www.google.com/search?sca_esv=4991a7ad233a5427&sxsrf=AHTn8zpiIlny93_UDfqfvjyV8Zit7fx24w:1747255237467&q=tabletop+fumehood&udm=2&fbs=ABzOT_CWdhQLP1FcmU5B0fn3xuWp5u5rQsC2YJafWTbyNSy6G3Vsi155b_IyTtSTnvQaXi8pqHe_O2hfOzwUB6ozx76J1AC2lHBIr4M8ARN1C70pOXO_STRl_VvYXPOJRpGgKQgh0vygyTT3DPXHVLVFjqWXnNLjJQJuciOonyIffrtiH1MgCmv8SFNr6npZ_ISgA83w8yyH8a87MSQW9H5Oohdabjy_cw&sa=X&ved=2ahUKEwiNn4v-6KONAxX5v4kEHfqYJ5QQtKgLegQIERAB&biw=1198&bih=588&dpr=2.14) (?)
- Remove all panels on OT-2 to avoid vapor buildup (?)

Excuse the fly-by comments

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